Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus
نویسندگان
چکیده
منابع مشابه
Kinetic analysis of glycine receptor currents in ventral cochlear nucleus.
Glycine plays an important role as an inhibitory neurotransmitter in the ventral cochlear nucleus. However, little is known about the kinetic behavior of glycine receptors. The present study examines the kinetics of the native inhibitory glycine receptors in neurons of the ventral cochlear nucleus, using outside-out patches from acutely dissociated cells and a fast flow system. Steps into 1 mM ...
متن کاملAge-related changes in the inhibitory response properties of dorsal cochlear nucleus output neurons: role of inhibitory inputs.
Age-related hearing loss frequently results in a loss in the ability to discriminate speech signals, especially in noise. This is attributable, in part, to a loss in temporal resolving power and ability to adjust dynamic range. Circuits in the adult dorsal cochlear nucleus (DCN) have been shown to preserve signal in background noise. Fusiform cells, major DCN output neurons, receive focused gly...
متن کاملGlycine immunoreactivity of multipolar neurons in the ventral cochlear nucleus which project to the dorsal cochlear nucleus.
Certain distinct populations of neurons in the dorsal cochlear nucleus are inhibited by a neural source that is responsive to a wide range of acoustic frequencies. In this study, we examined the glycine immunoreactivity of two types of ventral cochlear nucleus neurons (planar and radiate) in the rat which project to the dorsal cochlear nucleus (DCN) and thus, might be responsible for this inhib...
متن کاملDorsal cochlear nucleus hyperactivity and tinnitus: are they related?
PURPOSE Eight lines of evidence implicating the dorsal cochlear nucleus (DCN) as a tinnitus contributing site are reviewed. We now expand the presentation of this model, elaborate on its essential details, and provide answers to commonly asked questions regarding its validity. CONCLUSIONS Over the past decade, numerous studies have converged to support the hypothesis that the DCN may be an im...
متن کاملUltrastructural and quantitative age-related changes in capillaries of the dorsal lateral geniculate nucleus.
An ultrastructural and quantitative study of age-related changes in the capillaries of the dorsal lateral geniculate nucleus was carried out using male Wistar rats aged 3, 24, and 28 months. The most important structural changes were found in the basal lamina: thickenings either homogeneously distributed or in specific points; spurs towards the astrocyte sheath; and osmiophilic membrane-like in...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2009
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2009.01.079